Disease-Ancestry Network - DANCE

GWAS-hits, human complex phenotypes and population genetic variability in a Network-based approach.

In DANCE, we implement a combination of filters to explore the Disease-Ancestry Network, as described below. The fluxogram of querying in DANCE is presented in the figure. We also present below two tutoriais with some examples of querying DANCE data and networks.

To perform a query, we implemented a combination of six filters: Network, Ancestry, Gene, SNP – Risk Allele, Phenotypes, and Neighborhood. Network is the broader filter, which includes the options SNP-Disease Network and Disease-Disease Network.

Setting the Network filter to SNP-Disease Network option, the searches can be refined by choosing an Ancestry filter: Risk allele frequencies in Africans, Asians or Europeans; pairwise Fst between African-European, African-Asian, and European-Asian. Finally, Gene, SNP-Risk Allele or Phenotype filters can be applied to narrow the resulting network view to the topics of interest. The Neighborhood filter can be set to 0 (to visualize only the network of the phenotype selected) or to 1 (to visualize shared SNP-risk allele associations between the phenotype selected and other phenotypes).

Setting the Network filter to Disease-Disease Network option, the searches can be refined by choosing either All phenotypes option or a specific phenotype to investigate the Jaccard Coefficient if the phenotype shares SNps with other phenotypes.

DANCE - Supplementary Material